Mass Spectrometry

Photo by Penny Jennings-UCLA Department of Chemistry and Biochemistry.
The Mass Spectrometry and Proteomics Laboratory of the Molecular Instrumentation Center provides services and analytical techniques for the identification and quantification of a wide range of samples, from small molecules to large biomolecules for the UCLA researcher community, other academic institutions, and commercial enterprises. We have eleven state-of-the-art mass spectrometers for different types of analysis:
  • Small molecule mass measurement:
    • Agilent GC-Ion trap, Agilent GC-TOF, Waters LC-TOF, Thermo DART-Orbitrap, Agilent 6545 LC-QTOF

  • Small molecule quantification with MRM mode:
    • Sciex 4000 QTRAP QQQ, Sciex API 4000 QQQ

  • Trace metal quantification:
    • Agilent QQQ ICP-MS

  • Peptides and intact proteins analysis:
    • Bruker MALDI-TOF, Agilent 6530 LC-QTOF, Thermo Q Exactive plus Orbitrap

  • Metabolomic analysis:
    • Thermo Q-Exactive plus Orbitrap MS coupled with Thermo Vanquish UPLC, Agilent 6545 LC-QTOF
  • Proteomic analysis:
    • Thermo Q-Exactive plus Orbitrap MS coupled with Thermo Ultimate 3000 nanoLC
Instrumentation is available for 1D and 2D gel electrophoresis.

MIC staff offer instrumentation training, analysis service, and consultation for sample preparation, experiment design, data mining, and operation of the various instruments.